Hepatocyte Growth Factor Induces Resistance to Anti-Epidermal Growth Factor Receptor Antibody in Lung Cancer
نویسندگان
چکیده
منابع مشابه
Hepatocyte growth factor induces resistance to anti-epidermal growth factor receptor antibody in lung cancer.
INTRODUCTION Epidermal growth factor receptor (EGFR) is an attractive drug target in lung cancer, with several anti-EGFR antibodies and small-molecule inhibitors showing efficacy in lung cancer patients. Patients, however, may develop resistance to EGFR inhibitors. We demonstrated previously that hepatocyte growth factor (HGF) induced resistance to EGFR tyrosine kinase inhibitors in lung cancer...
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PURPOSE The resistance to selective EGFR inhibitors involves the activation of alternative signaling pathways, and Akt activation and VEGF induction have been described in EGFR inhibitor-resistant tumors. Combined inhibition of EGFR and other signaling proteins has become a successful therapeutic approach, stimulating the search for further determinants of resistance as basis for novel therapeu...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2012
ISSN: 1556-0864
DOI: 10.1097/jto.0b013e3182398e69